After weeks of speculation, he revealed he had suffered a relapse of ulcerative colitis, an intestinal disease that led to his resignation during his first term as prime minister in 2007. His departure leaves a potential power vacuum in the ruling Liberal Democratic Party (LDP) at a crucial time for Japan. Nicknamed "the Prince", Shinzo Abe hails from political royalty as the son of former Foreign Minister Shintaro Abe and grandson of former Prime Minister Nobusuke Kishi.
Mr Abe, 65, was first elected to parliament in 1993, and in 2005 he became a cabinet member when then Prime Minister Junichiro Koizumi appointed him to the high profile role of chief cabinet secretary.